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IMPROVING HEALTH FOR VERY PRETERM CHILDREN IN EUROPE

Perinatal outcomes

Neonatal morbidity and mortality in advanced aged mothers - Maternal age is not an independent risk factor for infants born very preterm.
Nourkami-Tutdibi N, Tutdibi E, Faas T, Wagenpfeil G, Draper ES, Johnson S, Cuttini M, El Rafei R, Seppänen AV, Mazela J, Maier RF, Nuytten A, Barros H, Rodrigues C, Zeitlin J, Zemlin M.
Front Pediatr. 2021 Nov 15;9:747203. doi: 10.3389/fped.2021.747203. eCollection 2021.

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Mode of delivery and adverse short- and long-term outcomes in vertex-presenting very preterm born infants: a European population-based prospective cohort study.
Wolf HT, Weber T, Schmidt S, Norman M, Varendi H, Piedvache A, Zeitlin J, Huusom LD; EPICE Research Group. 
J Perinat Med. 2021 Jul 20. doi: 10.1515/jpm-2020-0468. Online ahead of print.PMID: 34280959

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Variation in very preterm extrauterine growth in a European multicountry cohort.
El Rafei R, Jarreau PH, Norman M, Maier RF, Barros H, Reempts PV, Pedersen P, Cuttini M, Zeitlin J; EPICE Research Group.
Arch Dis Child Fetal Neonatal Ed. 2021 May;106(3):316-323. doi: 10.1136/archdischild-2020-319946. Epub 2020 Dec 2.

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Breastfeeding outcomes in European NICUs: impact of parental visiting policies.
Cuttini M, Croci I, Toome L, Rodrigues C, Wilson E, Bonet M, Gadzinowski J, Di Lallo D, Herich LC, Zeitlin J; Effective Perinatal Intensive Care in Europe (EPICE) research group. 
Arch Dis Child Fetal Neonatal Ed. 2019 Mar;104(2):F151-F158.


OBJECTIVE: The documented benefits of maternal milk for very preterm infants have raised interest in hospital policies that promote breastfeeding. We investigated the hypothesis that more liberal parental policies are associated with increased breastfeeding at discharge from the neonatal unit. 

DESIGN: Prospective area-based cohort study 

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Mode of delivery and mortality and morbidity for very preterm singleton infants in a breech position: A European cohort study.
Schmidt S, Norman M, Misselwitz B, Piedvache A, Huusom LD, Varendi H, Barros H, Cammu H, Blondel B, Dudenhausen J, Zeitlin J, Weber T; Effective Perinatal Intensive Care in Europe (EPICE) research group. 
Eur J Obstet Gynecol Reprod Biol. 2019 Jan 11.


OJECTIVE: Caesarean section (CS) may reduce mortality and morbidity for very pretemr breech infants, but evidence is inconclusive. We evaluated neonatal outcomes for singleton breech infants by mode of delivery in a Europan cohort. 

STUDY DESIGN: Data come from the EPICE population-based cohort of very preterm births in 19 regions in 11 European countries (7770 live births). The study population was singleton spontaneous-onset breech births at 24-31 weeks gestational age (GA) without antenatal medical complications requiring caesarean delivery (N = 572). Mixed-effects regression models adjusting for maternal and pregnancy covariates and propensity score matching was used to examine the effect of (1) CS and (2) a unit policy of systematic CS for breech presentation by GA. The primary outcome was a composite of in-hospital mortality, intraventricular haemorrhage grades III & IV or cystic periventricular leukomalacia. Secondary outcomes were each component separately, five minute Apgar score below seven and mortality within six hours of delivery. 

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